Profhilo vs Polynucleotides: Which Treatment Is Right for Your Skin?

If you’re looking for advanced skin treatments in Beckenham, you’ve likely come across Profhilo and polynucleotides (salmon sperm facial). As aesthetic medicine continues to evolve, treatments are increasingly focused on improving skin quality and stimulating natural regeneration, rather than simply adding volume. At SAYA Aesthetics, both treatments are popular for improving skin quality, hydration and overall rejuvenation—but they work in different ways. Understanding these differences helps ensure patients receive the most appropriate treatment for their skin goals.

What is Profhilo?

Profhilo is an injectable treatment containing a high concentration of pure hyaluronic acid, designed to deeply hydrate the skin and stimulate collagen and elastin production.

Unlike traditional dermal fillers, Profhilo does not add volume or reshape facial features. Instead, it spreads beneath the skin to improve overall skin quality, hydration, and elasticity.

Key benefits of Profhilo

• Deep skin hydration
• Improved skin firmness
• Increased collagen and elastin production for firmer skin
• Natural skin rejuvenation

Profhilo is often used to treat areas such as the face, neck, and hands, where skin laxity and dehydration are common concerns. You can read more about Profhilo here.

What are Polynucleotides?

Polynucleotides are regenerative injectable treatments derived from purified DNA fragments. They work by stimulating the skin’s natural repair processes at a cellular level.

They encourage fibroblast activity (the cells responsible for producing collagen and elastin) and support the skin’s natural healing processes.

Key benefits of Polynucleotides

• Skin regeneration and repair
• Improved skin elasticity and strength
• Reduce inflammation
• Enhance overall skin quality

Polynucleotides are particularly effective for delicate areas like under the eyes and for patients concerned with skin damage or ageing. You can read more about Polynucleotides here.

How do they work differently?

While both treatments aim to improve skin quality, their mechanisms are different.

Profhilo

Works primarily by hydrating the skin and stimulating collagen and elastin production through hyaluronic acid.

Polynucleotides

Work at a cellular level, encouraging tissue repair and regeneration while improving the skin’s structure.

In simple terms:

• Profhilo focuses on hydration and skin firmness
• Polynucleotides focus on cellular repair and regeneration

So, which treatment is best for you?

The best treatment depends on your skin concerns and treatment goals.

Profhilo may be ideal if you:

• Have dehydrated or crepey skin
• Want improved skin hydration and glow
• Are noticing early skin laxity
• Want overall skin rejuvenation

Polynucleotides may be ideal if you:

• Have delicate or damaged skin
• Want to improve skin texture
• Are concerned about under-eye skin quality
• Are looking for regenerative skin repair

In many cases, these treatments can also complement one another as part of a personalised skin rejuvenation plan.

The rise of regenerative aesthetics

Both Profhilo and polynucleotides represent the growing trend towards regenerative aesthetics, which focuses on improving the skin’s underlying health rather than simply treating visible concerns.

By stimulating collagen production and supporting the skin’s natural repair mechanisms, these treatments provide subtle, natural-looking improvements over time.

 How many treatments will you need?

– Profhilo is typically performed in 2 sessions, spaced 4 weeks apart

– Polynucleotides usually require a course of 3 sessions for best results

Maintenance treatments are usually once every 6 months.

Regenerative treatments at SAYA Aesthetics

At SAYA Aesthetics, treatment plans are carefully tailored to each individual to ensure the most appropriate approach to skin rejuvenation.

Whether through Profhilo, polynucleotides, or other regenerative treatments, the goal is always to enhance skin health, natural beauty, and long-term results.

Profhilo and Polynucleotides in Beckenham

At SAYA Aesthetics, we offer both Profhilo and polynucleotide treatments tailored to your individual skin concerns. Whether you’re looking to improve hydration, treat early ageing or restore skin health, our expert doctor-led approach ensures natural, long-lasting results.  

✔ Not sure which treatment is right for you?

Book a personalised consultation at SAYA Aesthetics, and we’ll create a treatment plan tailored to your skin goals.

Click here to book your consultation.

FAQs

Is Profhilo better than Polynucleotides?

It depends on your skin goals—Profhilo is better for hydration, while polynucleotides focus on repair and regeneration.

Can I have both treatments?

Yes, many patients benefit from combining both as part of a long-term skin plan.

How long do results last?

Results typically last around 6 months, depending on your skin and lifestyle.